Analgesic and systemic effects of xylazine, lidocaine and their combination after subarachnoid administration in goats.
نویسندگان
چکیده
The objective of the study was to determine the analgesic and systemic effects of subarachnoid administration of xylazine hydrochloride (XY), lidocaine hydrochloride (LI) and their combination (XYLI) in goats. Six healthy goats were used in a prospective randomised study. Three treatments were administered to each goat, with 1-week intervals between each treatment. Treatments consisted of 0.1 mg/kg xylazine, 2.5 mg/kg lidocaine and a combination of xylazine 0.05 (mg/kg) and lidocaine (1.25 mg/kg). Analgesia, ataxic, sedative, cardiovascular and respiratory effects, and rectal temperature were evaluated before (baseline) and at 5, 10, 15, and 30 min after subarachnoid injection, and then at 30-min intervals until loss of analgesia occurred. Lidocaine induced analgesia in 3.1 +/- 1 min (mean +/- SD), which lasted for 66 +/- 31 min. Heart and respiratory rates and blood pressure remained unchanged after lidocaine-induced analgesia. Xylazine induced analgesia in 9.5 +/- 2.6 min and xylazine-lidocaine in 3.2 +/- 1.2 min. Xylazine-lidocaine-induced analgesia lasted longer (178.3 +/- 37 min) than that induced by xylazine (88.3 +/- 15 min). The XYLI treatment induced prolonged motor blocking (115 min), more than the XY (80 min) and LI (90 min) treatments. Both xylazine and xylazine-lidocaine caused significant decreases in the heart and respiratory rates, but not in blood pressure. The combination of xylazine (0.05 mg/kg) and lidocaine (1.25 mg/kg) can be administered subarachnoidally (between last lumbar vertebra and 1st sacral vertebra) to produce prolonged (> 2.5 h) analgesia of the tail, perineum, hind limbs, flanks and caudodorsal rib areas in goats. Despite the prolonged analgesia, using this combination is desirable for relieving postoperative pain, but it may be a disadvantage due to a motor block when dealing with goats.
منابع مشابه
Comparison the analgesic effects of lidocaine, xylazine and their combination used into the epidural space in rabbits.
Objective: Addition of the drugs to lidocaine to induce epidural analgesia in order to elongate and enhance the analgesia has been investigated previously. The objective of this study was to compare the effects of epidurally administered xylazine either in combination of lidocaine or alone in rabbits. Design: Experimental study Animals: Twelve healthy and adult male New Zealand white strain rab...
متن کاملComparison of Lidocaine, Xylazine, and a Combination of Lidocaine and Xylazine for Caudal Epidural Analgesia in Dromedary Camels
Objective- This study was performed to investigate the analgesic effects of lidocaine, xylazine and lidocaine/xylazine combination in epidural anesthesia in dromedary camels. Design- Experimental Study Animals- Fifteen healthy immature dromedary camels Methods- The camels were randomly designed in 3 equal groups. In group L: lidocaine 2% (0.22 mg/kg), in group X: xylazine 2% (0.17 mg/kg), an...
متن کاملXylazine-Lidocain Combination for Retrobulbar Block in Goats
Objective- This study was performed to investigate the analgesic effects of lidocaine, xylazine and lidocaine/xylazine combination in eye regional anesthesia. Design- Experimental Study. Animals- Twenty adult goats were randomly designed in 4 groups. Procedures- In group L: 10 ml mixture of lidocaine 2% (5 mg/kg bw) and normal saline, In group LX: 10 ml mixture of lidocaine 2% (5 mg/k...
متن کاملComparison of Caudal Epidural Administration of Lidocaine and Xylazine to Xylazine/Ketamine Combination in Donkey (Equus asinus)
Objective- Evaulation of analgesic and sedative characteristics of xylazine/ketaminecombination for caudal epidural analgesia in comparison with two routine agents in donkey.Design- Cross over study.Animals- Five healthy adult donkeys of both sexes with body weights ranging from 150-200 kg.Procedures- Three treatments [lidocaine HCl 2% (0.22 mg kg^-1), xylazine HCl 2% (0.17 mg kg^-1) and xylazi...
متن کاملCaudal Extradural Analgesia with Lidocaine, Xylazine, and a Combination of Lidocaine and Xylazine in the Iranian River Buffalo (Bubalus bubalis)
Objective- To compare the time of onset, duration of action and the extent of analgesia produced by a lidocaine/xylazine combination with that produced by lidocaine and xylazine alone after injection into the caudal extradural space of the Iranian river buffalo. Design- Observer-blind prospective descriptive trial, Latin square design. Animals- Eleven adult (aged over 2 years) female non-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of the South African Veterinary Association
دوره 76 2 شماره
صفحات -
تاریخ انتشار 2005